Anxiety & Stress: Scientific Research & Clinical Trials

Anxiety

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug

Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder

Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation.

Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa

Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

A Systematic Review of Plant-Derived Natural Compounds for Anxiety Disorders.

The Endocannabinoid System and Anxiety

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders

Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults.

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors.

Stress

Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders.

Endogenous cannabinoid signaling is essential for stress adaptation.

Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output.

Down regulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress.

Neuromodulators, stress and plasticity: a role for endocannabinoid signalling.

Endocannabinoids and stress.

Stress regulates endocannabinoid-CB1 receptor signaling.

Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus.

Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance.

Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression.

Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.