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Denamarin For Dogs: How Does It Support Liver Function?

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Denamarin For Dogs: How Does It Support Liver Function?

Denamarin for dogs is a supplement given to pets that need liver support. It is a medication that can help increase antioxidants in the body that assist with liver function. Vets often prescribe a number of tablets for certain conditions in which the liver is being affected negatively.

This supplement is often in veterinary medicine used for liver failure, liver disease, liver support, and to protect liver cells. It can reverse liver damage in some cases. This article will make you a smart customer, will discuss what Denamarin tablets provide, and if it's right for your dog or cat.

Denamarin for Dogs | Innovet Pet

What Is Nutramax Denamarin Used For in Dogs and Cats

A prescription supplement from Nutramax laboratories, Denamarin is a drug prescribed by a veterinarian for liver disease or damage and is often given to both cats and dogs.

Nutramax Denamarin tablets have been shown to prevent or reverse liver damage, in some cases, and help elevate liver enzymes count and supplement an overall healthy lifestyle in both cats and canines.

Denamarin For Dogs - How Does It Work?

Nutramax Denamarin tablets for dogs works by using s-adenosylmethionine and silybin to strengthen liver health. Adenosylmethionine and silybin A B work together to increase liver functions that are crucial to the healthy functioning of the liver organ.

This supplement is relatively low-risk for canines to take for their liver support and functioning needs. Adenosylmethionine and silybin tablets can increase liver function and even support brain functioning.

What Causes Liver Disease In Dogs?

Unfortunately, liver disease is dangerous for a dog's health. Low glutathione, essential amino acids, are partly responsible for this disease. Glutathione can be reduced through stress, toxins, and even a poor diet. Even a tough customer who seems strong can be at risk.

A pet's liver is what helps to purify the blood, allow for food digestion, and eliminates waste from the body. This is why an unhealthy liver can be quite damaging to the liver health and livelihood of your pet. If you need to talk to your vet about liver disease, come in with some ideas.

Most Common Causes Of Canine Liver Disease

The most common causes of canine liver disease are:

  • Metabolic disease
  • Bacterial infections
  • Infections that are viral
  • Trauma or injury
  • Toxicity (chemicals)
  • Drugs (like acetaminophen)
  • Genetics
  • Abnormalities (congenital malformation)
  • Over-vaccination
  • Low glutathione

Denamarin for Dogs | Innovet Pet


In most cases, improper diet due to nutritional imbalance caused by parasites or intestinal issues is some of the more typical causes of liver damage. This is not good for dogs that have an especially sensitive liver function.

Also, giving them too much food at once isn't good for them. Your feeding schedule should follow the guidelines given by vets and as recommended by serving sizes and weights.

It is crucial to follow the veterinarian's recommended guidelines and food choices if your dog has been diagnosed with liver disease. Sometimes, it's recommended to make homemade foods that have specific ingredients. There are holistic veterinarians that can help with diet recommendations. 

The accidental ingestion of poison or toxic chemicals can cause liver damage. It can range from minor to severe. If a dog accidentally ingests poison they need to be rushed to the vet emergency room as soon as possible. Pet parents that have chemicals or poisons around the home should lock them up or place them on high shelves.


Some medicines, like acetaminophen, can cause liver damage. Pet parents that have canines taking acetaminophen need to pay close attention to how their pet reacts and let their veterinarian know if they have adverse reactions to this medication. Make sure to thoroughly count the amount and only give your dog the recommended dosage.

Denamarin for Dogs | Innovet Pet


There are dog breeds that are more susceptible to liver disease. West Highland, Skye, Yorkshire, and Bedlington (all Terrier breeds) are at higher risk of developing liver disease.

Also, some large dogs like Dobermans have a genetic predisposition to these conditions. These breeds are at a higher risk for liver disease because their bodies are not able to eliminate copper efficiently which causes copper toxicity within the body.


Over-vaccination is a real risk factor. For example, if a pet owner hasn't kept count of the vaccination administration records, has lost them, or they don't know when the last time their furry friend was vaccinated. Or, sometimes a person adopts a pet and they don't know their vaccination record at all. This leads to a pet getting vaccinated too many times. 

Over-vaccination can cause liver disease and pet parents should do whatever they can to keep accurate record of their dog's vaccinations. Ask your vet for an updated list of vaccines.


Bacterial and viral infections are usually things that cannot be helped. They come out of nowhere and make precious pets sick. Fortunately, most infections go away with the proper treatment without any long-term side effects. However, that is not always the case and sometimes dogs suffer liver damage, particularly leptospirosis, infectious canine hepatitis, and canine adenovirus 1.

Symptoms of Liver Disease In Dogs

The symptoms of liver disease greatly vary in severity and type. Most pet parents are unable to tell that their dog, cat, or other pet is suffering from this until they become very ill. Some of the symptoms resemble many other ailments.

The most common initial symptoms of liver disease are lack of appetite, diarrhea, vomiting, lethargy, and dark urine. A late-stage symptom of liver disease is jaundice (yellow eyes). If you notice that your beloved pet has yellowed eyes, it is essential to get them to the veterinarian right away.

It is a good idea to discuss a diet with the veterinarian and begin exercising them more often. Vets will usually suggest a more organic, less processed, diet that has less carbohydrates and grains than most commercial dog foods. Diabetic dogs will almost always have to start a healthier diet right away and there is a link between diabetes and liver disease.

Trauma to the body or the liver can also cause liver disease. These injuries can leave long-lasting injuries and side effects. Canines that have sustained bodily trauma may need more than the average amount of veterinary visits to ensure they're doing well. Pet parents will have to keep a close eye on their beloved pet after an injury to the body. Remember that emergency vet visits are unpredictable, so it’s better to be prepared for out-of-pocket expenses beforehand with a pet emergency fund or other pet insurance alternatives.

Denamarin for Dogs | Innovet Pet

Denamarin for Dogs - Primary Uses

Nutramax Denamarin tablets for dogs are used for liver disease and liver damage. Pups with genetic conditions, liver abnormalities, and other problems sometimes have chronic liver disease. These dogs can benefit from a Denamarin supplement that has been shown to help with raising liver enzymes and fundamental functions so that they are able to manage their condition.

Denamarin provides relief from liver damage and even cell regrowth. Canines that have liver damage from trauma or illness can sometimes see a reversal of the condition. In many cases, the damage can be stopped in its tracks and no further damage will occur.

Denamarin or Milk Thistle For Dogs?

The compound silybin phosphatidylcholine is present in Denamarin and milk thistle (unlike the standardized milk thistle extract). Denamarin has been shown to have an added compound, s-adenosylmethionine, that helps brain and liver function, and is essential for liver health formed when metabolized. Because of this, adenosylmethionine-rich Denamarin tablets from Nutramax are a better option than milk thistle.

Milk thistle, a liver supplement for dogs doesn't have s-adenosylmethionine, so it does not offer as many health benefits as Denamarin. Silybin phosphatidylcholine and phosphatidylcholine complex are both active ingredients that supports oxidative balance but always consult with a vet before administration of a new med. Silybin A B tablets like Denmarin provide optimal absorption.

Denamarin for Dogs | Innovet Pet

Can Denamarin Help With Liver Disease

Silybin-infused Denamarin tablets are not a cure for liver disease. But Denamarin has been shown to help with reversing liver damage and with elevating enzymes that maintain a health oxidative balance. This helps support liver function to help a dog that is dealing with this condition. However, there is no known cure for liver disease.

Think of Denamarin and silybin as a supplement to your pet's overall well-being.

Cell Repair and Regeneration

Denamarin and silybin pills have been shown to help protect liver cells and even repair liver cells from cell death. Phosphatidylcholine complex is a naturally occurring chemical in Denamarin pills that stops liver cells from cell death.

Dosage and Types of Nutramax Denamarin For Dogs

Dena marin is a prescription medication in tablet form that can be prescribed by a veterinarian for either a cat or canine. As the customer, you can choose the proper size tablet for your best friend.

Denamarin Tablets

The dosage of Denamarin tablets will vary based on the weight and age of your dog. For cats and small pups up to 12 lbs one 90 mg tablet containing 9 mg of silybin A B is sufficient. A pet over 12 lbs will take a number of tablets to be determined by the vet.

The prescribing service should also give the customer instructions on dosage and frequency. A Denamarin supplement should be given on an empty stomach at least one hour before feeding. Always store in a cool dry place that even the cat cannot reach.

Chewable Tablets

These chewable tablets will provide consistent optimal absorption when administered 12 hours apart from each dose.

It is imperative to follow these instructions and have the pills given on an empty stomach so that your dog doesn't accidentally get too many Denamarin tablets. Separate the administration of pills at least one hour before giving food.

Side Effects of Denamarin For Dogs

There are not any significant side effects for dogs that take Denamarin. However, canines that are given too much Denamarin may have vomiting and diarrhea. This is why it is so crucial to stick to the prescription instructions and follow them to the letter.

If you are worried that your pet has taken too much, it is a good idea to check in with the veterinarian. However, there have been no reported major side effects from taking too much Denamarin and it is likely that your dog will be fine as long as the overdosing is stopped.

Denamarin for Dogs | Innovet Pet

Denamarin for Cats and Small Dogs

Can I give my cat chewable tablets of Denamarin too? Small dogs (under 15 lbs) and cat breeds can stomach at least one chewable tablet. Denamarin for cats works the same way as it does for dogs, providing liver support. Just beware that small dogs under 12 lbs and cats under 8 lbs will require much smaller dosages than large ones.

Denamarin for dogs and cats is a safe and easy way to support your pet's liver. Small dogs and cats under 10 lbs can take a chewable tablet of Denamarin on an empty stomach at least once every 12 hours to help protect your pet's liver cells through silybin phosphatidylcholine. There are no known side effects for cats according to veterinarian medicine, but always consult your personal vet.

Should I Give My Dog Denamarin?

Denamarin has been shown as a well-known and recognized prescription for liver disease. In studies, it's been shown to be effective with raising liver enzymes, improving liver function, and even reversing liver damage. It has no major side effects. Therefore, it is likely perfectly fine and safe to give your dog or cat a Dena marin tablet.

Pet parents that are worried about the horrendous side effects of some prescriptions do not have to worry about it with this medication as they do with others. However, the ultimate decision on whether you should give your dog Denamarin should be between you and your trusted vet.

It is important to discuss whether the supplement will be beneficial to your dog's liver support. If your pet's veterinarian recommends it, then it is probably a wise idea to give a Denamarin supplement to your canine or cat as prescribed. After all, every pet parent wants to see their dog or cat get better after suffering from a medical condition that can be painful and difficult.

Denamarin for Dogs | Innovet Pet

What Else Can I Do For My Dog with Liver Disease?

Dogs and cats that have liver diseases can live a healthy life for many years. They can live that long and healthy life with the help of pet parents that give them the proper medications and the best foods for their health condition. Foods rich in vitamin E have been shown to enrich a pet's liver. And a healthy liver function is, of course, the main goal.

Also, giving them plenty of attention and love always helps a lot! There are proven studies that show dogs that are given attention and loving care are happier and healthier pets. That is something that a pet parent can do easily out of pure love and there is no cost to adding a little extra affection and care.

CBD as a Natural Aid for Dogs with Liver Conditions

Cats and dogs that have liver conditions often deal with discomfort or pain of some sort. Unfortunately, pet parents can't always tell when their dog is in pain or suffering. A pet parent customer seeks to purchase something organic and natural to help them with their pet's well-being. This is because natural options are without chemicals that can have devastating consequences.

CBD supplements are an example of a natural aid that is chemical-free and completely organic. It is derived from hemp extract and gives users amazing health benefits. There are many studies that indicate CBD supplements help with pain, inflammation, nausea, and much more.

CBD is being investigated all over the world for many uses. However at this time, as the manufacturer of CBD products, we are not allowed to discuss that subject publicly nor we are not allowed to imply that CBD can be used for any specific treatment.

CBD Oil for dogs is specially formulated for pets in mind. It allows for easy dosing and can be given to dogs in their food or with their favorite treat. There is zero THC and are no known side effects and that means that pet parents don't have to worry about any type of “high” and they also do not have to worry about side effects. There is really no downside to giving CBD supplements. There are proven health benefits and no side effects and you don't have to keep count of a large number of tablets.

Denamarin for Dogs | Innovet Pet

Many pet parents have seen improvements in overall health, and brain health after a short period of time once they have begun taking CBD supplements. Dogs and cats that have liver disease or liver damage can experience an improvement in their well-being after taking this product and can give it to them without worry.

Final Thoughts on Denamarin for Dogs

Denamarin for dogs and cats is a viable and helpful prescription that has shown effectiveness in treating liver disease and liver damage. It has been given as a prescription by vets for many years and has been tested in numerous studies as a safe and effective medication. There are no severe side effects to worry about and that is quite amazing in that many prescriptions do have a long list to count of dangerous side effects.

In summation, Denamarin is safe to give to your dog or cats and can have a positive impact on their health. Pet parents who are given this prescription for their best friend can move forward with confidence that it should help their pet's health, help protect liver cells, and improve their liver function.

You can safely purchase CBD for dogs and cats at Innovet as an informed customer if aggressive supplements are not the right choice for your pet's liver - just always check with your vet first!



Approved by:

Dr. Ivana Vukasinovic

Doctor of Veterinary Medicine, University of Belgrade

Ivana Vukasinovic grew up in Serbia and attended the University of Belgrade where she received a degree in Veterinary medicine in 2012 and later completed surgical residency working mostly with livestock. Her first year of practice was split between busy small animal practice and emergency clinic, and after two more years of treating many different species of animals, she opened her own veterinary pharmacy where an interest in canine and feline nutrition emerged with an accent on fighting animal obesity. In her free time, she acts as a foster parent for stray animals before their adoption, likes to read SF books and making salted caramel cookies.


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The Innovet Team

Please do not ask for emergency or specific medical questions about your pets in the comments. Innovet Pet Products is unable to provide you with specific medical advice or counseling. A detailed physical exam, patient history, and an established veterinarian are required to provide specific medical advice. If you are worried that your pet requires emergency attention or if you have specific medical questions related to your pet’s current or chronic health conditions, please contact or visit your local/preferred veterinarian, an animal-specific poison control hotline, or your local emergency veterinary care center.

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