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Carprofen For Dogs: The Side Effects To Be Aware Of

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Carprofen For Dogs: The Side Effects To Be Aware Of

We love our pets! So of course, we want the best possible options for them when they're in pain, whether it's due to arthritis or other types of inflammation in the body. We want them to feel better, as quickly as possible, and with minimal side effects.

There are options out there that your vet can provide when it comes to handling your dog's pain. One of the top options is carprofen, which can also be known as Novox or Rimadyl.

There are also some other options on the market by the names of Vetprofen, Truprofen, and Rovera. Before giving your dog any of these carprofen varieties, it's important to know about the medication as well as the side effects that can occur with it.

Carprofen For Dogs: The Side Effects To Be Aware Of | Innovet Pet

What Is Carprofen?

Essentially, carprofen is used to treat pain in dogs and is known as an NSAID. That means that it's an anti-inflammatory medication that is non-steroidal in nature. It's made to help with a variety of inflammation issues that can bring your dog discomfort and pain.

Carprofen is one of many nonsteroidal anti-inflammatory drugs that is used in veterinary medicine. It is similar to other NSAIDs such as naproxen, ibuprofen, and ketoprofen.

Carprofen is commonly prescribed by veterinarians for the treatment of pain and inflammation in dogs. It is safe and effective for the relief of pain and inflammation associated with arthritis, hip dysplasia, and other joint diseases.

Carprofen works by inhibiting the production of prostaglandins, which are hormones that play a role in the inflammatory response. This reduces pain and inflammation while also helping to improve joint function.

Generally, when you notice side effects that occur as part of using carprofen, it indicates issues with the kidneys. You may have to pay close attention to notice some of these. Dogs at greatest risk for kidney problems are those that are dehydrated.

Nonsteroidal anti-inflammatory medications may also block the enzymes that help keep maintain normal homeostasis function.

Uses Of Carprofen For Dogs

Carprofen may be is used for a variety of things, at the discretion of your vet. However, a couple of the most common conditions that it is prescribed for are inflammation and pain.

IT is most commonly used to control postoperative pain and pain associated with osteoarthritis that can otherwise leave dogs with chronic pain.

Keep in mind that this medication isn't a cure for either situation. However, it can be used to ease the pain until your dog heals, or a solution for the osteoarthritis is found. You can think of it as similar to ibuprofen for humans, which may be able to help in small amounts, but doesn't resolve pain forever by itself.

Carprofen For Dogs: The Side Effects To Be Aware Of | Innovet Pet

How Carprofen Works

Like other NSAIDS on the market, carprofen is generally considered to involve cyclooxygenase activity. Essentially, they work by inhibiting the creation of prostaglandins that control the different responses in our bodies that can result in inflammation and pain. Consequently, it may be able to help keep that pain to a minimum.

Furthermore, it's important to know that not all NSAIDS handles all prostaglandins. Some are more selective, allowing renal and gastrointestinal systems to remain relatively normal while focusing on those that create inflammation.

Because of that, it's important to ask your vet exactly what the carprofen option being prescribed to your pet does.

What Is The Best Carprofen Dosage?

If you're new to using Carprofen for your dog, then it's important to make sure you use the correct dosage. While your vet will likely let you know how much carprofen to give your dog and when it never hurts to have an understanding of the dosage yourself.

The first aspect to know is that carprofen is offered in a few different doses, including 100mg carprofen, 75mg, and 25mg. That way, dogs of just about any size can get an amount that is suitable for them. Furthermore, it's usually offered as a chewable or tablet for easier administering.

Keep in mind that carprofen is not for humans, so it's not recommended that you take it yourself. There are plenty of over the counter options that are reliable for you. It's also a good idea to give your dog the carprofen with food, in order to help them digest it more easily.

Typically, the dosage for carprofen is 2mg for every pound your dog weighs on a daily basis. Otherwise, you can provide half that dose twice a day. For example, a 50lb dog would receive 100mg daily, but you could also choose to give them 50mg in the morning and 50mg in the evening.

Carprofen For Dogs: The Side Effects To Be Aware Of | Innovet Pet

Drug Interactions And Precautions With Carprofen

There are some times when it isn't a good idea to give your dog carprofen, such as when they have certain conditions, or if they are on certain other medications. Having an understanding of these situations can allow you to find the safest solution for your pet.

Situations where the potential for negative reactions increase are:

  • When dogs are prone to adverse reactions with other NSAIDs
  • If your dog is currently receiving other NSAIDs
  • If your dog is receiving steroids
  • When your dog is receiving nephrotoxic medicines
  • If your dog is using ACE inhibitors
  • When your dog receives anticoagulant medicines
  • If your dog has dehydration, bleeding disorders, hypoproteinemia, cardiovascular disease, renal disease or gastrointestinal diseases
  • When your dog is nursing or pregnant

Drug interactions are possible with some antibiotics, corticosteroids, and diuretics. Carprofen must be used with caution in dogs with pre-existing liver or kidney disease.

Clinical signs of adverse reactions occur within the first few days of starting treatment and may include vomiting, diarrhea, decreased appetite, and lethargy. If you notice any of these signs in your dog, contact your veterinarian immediately.

Carprofen For Dogs: The Side Effects To Be Aware Of | Innovet Pet

Carprofen Side Effects

For the most part, dogs that take carprofen tend to only experience side effects that are milder. However, NSAID medications like carprofen have yet to be fully studied or understood, so there are potential effects that we can't yet see.

Consequently, it's very important to make sure you understand the potential side effects that are known. That way, you can decide whether or not carprofen is right for your dog.

Common side effects of carprofen for dogs include vomiting, diarrhea, decreased appetite, and lethargy. Carprofen may also affect lab tests, such as thyroid levels, liver enzymes, blood cell counts, potassium levels, kidney values, and bleeding times.

In some rare cases, Carprofen can cause serious kidney damage. If you notice any of these side effects in your dog, please contact your veterinarian immediately. Carprofen is a relatively safe and effective medication when used as directed by a veterinarian.

Carprofen Effects On The Liver

This section focuses primarily on side effects that can result in your dog's liver. Typically, not many dogs experience these kinds of issues, only about .02%. In fact, carprofen is more likely to exacerbates pre-existing liver issues and create new ones.

If you're really set on using carprofen, consider pairing it with pet insurance plans that will cover any serious adverse reactions that may occur. To monitor your dog's liver health while taking carprofen, be sure to keep an eye on their liver enzymes and blood cell counts. Regular check-ups with the vet are also strongly advised.

However, it is important to know that a fourth of those issues are seen in Labrador Retrievers. So if your dog is of that breed, you'll want to really consider whether or not this is the right choice.

Common signs of liver issues from carprofen are as follows:

  • Jaundice, or yellowing of the nostrils, gums, or genitals
  • Decrease in appetite
  • Hepatoxicity
  • Vomiting
  • Abnormal results on any tests of liver function

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Effects On The Nervous System

These are effects that are highly important to keep in mind when you give your dog a carprofen dosage, or the dosage of a carprofen product like Novox for dogs, or Rimadyl, either generic or otherwise. In order to notice nervous system effects in your dog, you'll likely have to keep a close eye on them.

Some of the neurologic issues that can occur are:

  • Partial or full paralysis
  • Seizures
  • Disorientation
  • Balance loss, or lack of coordination
  • Head tilting
  • Wandering in circles
  • Falling or stumbling

Carprofen For Dogs: The Side Effects To Be Aware Of | Innovet Pet

Blood-Related Carprofen Side Effects

These are side effects or diseases that can result from Carprofen in the blood:

  • Thrombocytopenia, which can show up as bleeding, bruising or anemia
  • Nosebleeds
  • Hemolytic anemia, red blood cells that aren't working properly, or have a low count overall
  • Anemia as a result of blood loss, which can come from blood in urine, vomit or stools

Carprofen And Gastrointestinal Issues

These side effects tend to occur when the medication begins to interact with the small intestines and stomach. Typically, these effects can cease when you cease giving the carprofen product to your dog.

Make sure to speak with your vet if you notice these symptoms:

  • Diarrhea
  • Decrease in appetite
  • Tarry and black stools
  • Pancreatitis
  • Vomiting, especially if there is blood present
  • Constipation

Urinary Side Effects

Generally, when you notice side effects that occur as part of using carprofen, it indicates issues with the kidneys. Some of these effects may be subtle, so it's important to pay close attention.

Pet parents should also be aware that Carprofen could interfere with lab test and possible give incorrect kidney values.

Dogs who are dehydrated or on concomitant diuretic therapy are at greatest risk for kidney problems. If you notice any of the following side effects, please contact your veterinarian as soon as possible:

Urinary Side Effects Typically Include:

  • Higher frequency of urination
  • Incontinence of urine
  • Abnormalities of a tubular nature, or kidney failure
  • Blood showing up in the urine
  • Heightened levels of thirst
  • Urinary Tract Infection
  • Azotemia
  • Glomerular disease

Carprofen For Dogs: The Side Effects To Be Aware Of | Innovet Pet

Changes In Behavior With Carprofen

In some cases, using carprofen for your dog can result in some changes in your dog's behavior. Generally, these kinds of changes are a result of your dog feeling some kind of discomfort with the drug. If you notice these issues, then it can be a good idea to watch your dog make sure more serious symptoms don't follow. It can also be helpful to check in with your vet if you notice these changes.

Keep an eye out for these symptoms:

Carprofen Skin Issues

These kinds of conditions can show up in your dog's nail, hair, or skin. They are worth keeping an eye out for, as some can be particularly troublesome for your dog. Remember that if you are noticing these kinds of issues and feel concerned, it is always a good idea to contact your vet and make sure the symptom isn't a serious one.

The following are side effects that can occur on your dog's skin:

  • Heightened shedding
  • Skin lesions that are painful, raw or irritated
  • Necrotizing Vasculitis/Panniculitis
  • Increased scratching or chewing of the skin
  • Loss of hair
  • Bruises in the abdominal area

Carprofen For Dogs: The Side Effects To Be Aware Of | Innovet Pet

Signs Of Allergic Reaction To Carprofen

No matter what the medication is, some dogs can experience allergic reactions. On top of that, these reactions can sometimes be dangerous to your beloved companion.

Consequently, it's important to make sure you talk to your vet if the following issues occur in your dog after taking carprofen:

  • Hives
  • Swelling in the face
  • Skin redness

In extremely rare situations, negative reactions to carprofen can result in death, which makes it even more important that you let your vet know when these signs occur. The earlier you catch them, the better off your pet will be.

Signs And Treatment Of An Overdose

In addition to allergic reactions, it's also very important that you keep an eye out for a potential overdose.

The symptoms of an overdose of carprofen are as follows:

  • Diarrhea or stool that is black and tarry
  • Vomiting, especially if blood is involved
  • Lethargy
  • Lack of appetite
  • Abdominal pain
  • Malaise
  • Urinating or drinking at inappropriate times
  • Seizures

The treatments for an overdose can vary. Some treatment methods are:

  • Stomach pumping
  • Supportive care
  • Inducing vomiting
  • Charcoal slurry
  • Performance of blood values, such as chemistry, baseline, and CBC

Carprofen: Reported Problems

Montana And Angela

Montana was a husky prescribed with Rimadyl for issues with stiff legs. Early in the treatment, he reacted well but soon developed issues with a lack of appetite. Following that, he also began to show some neurological symptoms and ataxia. Due to liver destruction, Montana lost his ability to walk. He had to be euthanized to prevent further suffering. The creators of this medication attempted to pay Montana's owner off for her silence when it was reported.

Issues such as these are why it's important to look into natural pain relief possibilities for our beloved canine friends.

Smith & Cooper vs Pfizer

Smith and Cooper were the owners of a golden retriever named Sophie. Having sustained an injury to her knee, Sophie needed to receive surgery. Having gone through surgery without issue, Sophie was prescribed Rimadyl in order to allow her to heal with less pain.

However, much like Montana, Sophie ceased eating after taking the medication and began to vomit more frequently. While her owners stopped the medication, Rimadyl toxicity had already resulted in liver failure and the death of their beloved friend.

In an attempt to raise awareness about these issues, Smith and Cooper filed a lawsuit against Pfizer. In addition, they sought to provide information about Rimadyl to other pet owners through the use of brochures.

Carprofen For Dogs: A Final Thought

While for most, carprofen can be a helpful way to alleviate and treat pain on a temporary basis, there can be some cases in which it is very dangerous. As a result, it's important to make sure you understand all of the options available and only use Rimadyl, Novox, or other carprofen medications with the prescription and under the care of a vet.

In addition to that, watch your pet carefully for side effects and adverse reactions. It also can't help to look into natural options out there!


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1 comment
  • walter j sivigny

    We have a 13 year old female cockapoo. In the last 6 months she developed incontinence and an awful odor at times that the vet said was a leaking gland. Giving her medication was a chore also. She has had TWO radical knee surgeries about 6 years ago and thankfully she fully recovered her ability to run. The vet prescribed Carprofen but we never gave her much of it because she did not limp or show signs of pain. But recently she has and we grind the med into a fine powder and mix with food. As soon as we started that ALL OF HER PROBLEMS DISAPPEARED. NO INCONTINENCE OR GLAND PROBLEMS. Don’t know why but thank God it did.

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