TABLE OF CONTENTS
1. Is your pup taking medications on a regular basis?
2. Does it Interact with Additional Drugs?
3. How does CBD Affect Liver Enzyme Activity?
4. What Pharmaceuticals Will CBD Interact With?
5. How to Use CBD With Pets
6. Can CBD be Utilized Along with Other Supplements and Drugs?
7. How CBD Affects the Dose of Other Supplements and Drugs
8. When is it Time to Move the Cat or Dog Away from Their Medications?
9. Tips for Replacing Your Pet’s Prescription Medications With CBD
10. Basics of CBD Dosages
11. What Meds May CBD Replace?
12. Benefits of Weaning Off of Your Dog’s Meds With CBD
Is your pup taking medications on a regular basis?
If the answer is yes, you might’ve heard about CBD, as well as how some pet owners utilize it to slowly replace their pet’s prescription medication.
You can, as well.
Does it Interact with Additional Drugs?
Yes, it can.
Are you weaning dogs off Prozac? While CBD is a safe and natural compound, it’ll interact with additional drugs.
That’s because CBD affects the activity of certain liver enzymes which play a big part in metabolizing a broad array of drugs.
These enzymes are well-known as cytochrome P450 and assists in breaking down about 60 percent of all the medicines present in the market.
That includes anticonvulsants, NSAIDs, antidepressants, and more.
Research shows that CBD will inhibit the activity of those enzymes, thereby slowing down the rate by which the liver breaks down and processes other medicines.
This ultimately means the medicines remain inside the body for longer, potentially having extended effects.
The rate in which CBD affects the P450 liver enzyme activity will vary depending upon dosage and the presence of any additional medications inside the body.
Some of the medicines CBD will interact with involving NSAIDs, steroids, allergy medications, anesthetics, anti-anxiety, and anticonvulsant medications.
Can it Interact with Additional Medicines?
Below I will take a closer look into potential CBD drug interactions:
How does CBD Affect Liver Enzyme Activity?
The reason it’ll interact with additional pharmaceuticals is that CBD will affect the activity of a certain group of liver enzymes known as cytochrome P450.
This enzyme group has the job of metabolizing around 60 percent of all the medicines in today’s market.
That includes NSAIDs such as anti-epileptics such as diazepam; ibuprofen; antidepressants such as amitriptyline, and more.
Enzymes break these medications down by adding oxygen molecules to their structure.
The process is referred to as oxidization.
In oxidizing those compounds, cytochrome P450 makes the compounds more water-soluble and eventually easier for your kidneys to filter.
Pre-clinical research has proven that CBD will inhibit cytochrome P450 activity and therefore affect the liver’s capability of metabolizing other compounds.
As CBD enters your body, it also is metabolized by cytochrome P450 enzymes.
It’ll occupy the area of enzyme activity inside the liver and, consequently, stops the enzymes from breaking other chemicals down.
That means other pharmaceuticals typically metabolized by cytochrome P450 enzymes remain inside the body, as well as take effect for longer.
Note that the rate by which CBD affects those enzymes will greatly vary depending upon how the CBD was given and at which doses.
It also can vary depending upon the other pharmaceuticals being metabolized by your liver, as well as whether the CBD derives from a whole-plant supplement or isolate.
What Pharmaceuticals Will CBD Interact With?
As aforementioned, cytochrome P450 enzymes have the job of metabolizing around 60 percent of the medicines present in the market.
I cannot list all of those drugs here.
But, some of the most typical drugs which CBD may interfere with are:
- Some antibiotics
- Fentanyl and additional narcotics
- Benzodiazepines (such as anticonvulsants and anxiolytics)
- Antihistamines (such as allergy medicines)
- Steroids (such as Fludrocortisone and Prednisone)
Check out the Drug Interaction Table - Flockhart P450 for a complete listing. The listing has the pharmaceuticals that are processed by P450 enzymes and could possibly act together with CBD.
How to Use CBD With Pets
CBD is a very popular health supplement.
Inactivating the Endocannabinoid System-- shown to play an important part in everything from inflammatory processes to appetite regulation, CBD may have a broad array of health benefits.
- Metabolic regulation
- Relief from allergies
- Relief from stress and anxiety
- Anti-inflammatory effects
- … and much more.
Because cats and dogs have an Endocannabinoid System as humans do, they’re able to reap several of the same benefits from CBD as human beings can.
But if you plan to utilize CBD with your pet, you must be aware of how the supplement may interact with any additional supplements or medications your pet is consuming.
Be certain to ask the following questions before beginning to utilize CBD with your cat or dog:
- Are there additional alternative medicines your pet might take which will not interact with CBD?
- If it isn’t possible to take your pet off their regular meds completely, is it possible to adjust the dose to minimize the risk of a medication interaction?
- If there’s a risk of interaction, can you take your pet off their meds for a period while you give the CBD a try for a little while?
- Does your pet presently take any other medications or supplements? If the answer is yes, how are they metabolized and what are they? Ask your veterinarian about the specifics of how your dog or cat’s medications work and whether CBD possibly could interfere.
- Why do you actually want to give your pet CBD? Are you planning on using it as a day-to-day supplement or are you attempting to treat a certain medical symptom/condition?
Can CBD be Utilized Along with Other Supplements and Drugs?
That’s a complicated question.
CBD is considered to be a safe supplement and is typically used along with other medications or supplements.
As a matter of fact, research suggests that cannabinoids will assist in increasing the efficacy of some meds such as painkillers, for instance.
It’s possible to read more on the synergism of cannabinoids with additional pain meds in this 2013 study by Journal of Opioid Management paper.
The fact that CBD may synergize with additional drugs may be both problematic and positive.
Research has shown, for instance, that cannabinoids safely can increase the pain-relieving possibility for opioid meds.
That leads scientists to believe that cannabinoids such as CBD might assist in lowering opioid dosages in patients and aid them in slowly decreasing their dependence on those drugs.
In addition, the truth that cannabinoids interact with additional drugs might prove problematic.
As aforementioned, CBD will have an impact on liver enzymes and affect the rate by which the liver processes additional medications.
It could boost the odds of some meds causing side effects and potentially impact the dose at which those other meds should be consumed, seeing as they will remain inside the body for longer.
Unfortunately, there is a limited amount of research that has looked specifically at CBD and how it can interfere with the effects of additional medications.
There is even less research focusing especially on vet drugs.
Therefore, it really is essential to take some time to go over CBD with your veterinarian and allow them to help you make educated choices about how it might interfere with any additional meds your pet is consuming.
How CBD Affects the Dose of Other Supplements and Drugs
Before moving on to the subject of weaning off meds, I want to take a look into how CBD affects drug dosage.
It’s very important, seeing as some meds, such as anticonvulsants and chemotherapy drugs, often are offered at specific doses.
For example, while treating canines with cancer, veterinarians oftentimes take a lot of time to figure out the proper dose for their chemotherapy drugs.
This dosage ought to be strong enough to be as efficient as it can be, but small enough to minimize toxicity.
The medications used in chemotherapy are, similar to many additional meds, metabolized by cytochrome P450 enzymes inside the liver.
Thereby, using CBD along with chemotherapy might be risky because it might cause greater blood concentrations of the chemotherapy medications.
That means a safe dosage of chemotherapy might, possibly, become unsafe as used along with CBD.
Or that is what experimental research results inform us, at least.
Realistically, CBD is becoming increasingly popular among those with cancer, and the ones going through chemotherapy.
Those patients discover that CBD aids them in maintaining a healthy appetite, battle the lethargy and fatigue which chemotherapy oftentimes produces, manage pain, and more.
There’s little proof showing that CBD interferes with chemotherapy agents.
When is it Time to Move the Cat or Dog Away from Their Medications?
It’s a question heard from many pet owners.
When weaning dogs off of medications the answer to that obviously depends on the condition of your pet and the meds they’re taking.
If you determine that CBD might be beneficial for your pet, next you will have to look into what medications or supplements they’re presently taking.
Speak with your veterinarian about how these meds are processed inside the body and whether, given CBD’s liver enzyme effect, there’s a probability of an interaction.
In addition, search for the meds your dog is consuming on the P450 Flockhart Drug Chart.
If there’s a probability of a drug interaction, I would suggest weaning your pet off of their medication completely before beginning to use CBD.
Whether that’s feasible is going to depend on the condition of your dog, as most severe conditions can’t go untreated for too long.
If a drug interaction is not possible, you might want to start your dog on CBD in conjunction with their regular meds.
To do that, follow these outlined tips:
Tips for Replacing Your Pet’s Prescription Medications With CBD
There are numerous things to do to make your dog’s transition to CBD as seamless as it can be.
Below we list tips on utilizing CBD with your pet and weaning them off of their regular medicines:
Consult your veterinarian.
Check that CBD will help the ailment.
Begin with a small dose of CBD.
Gradually increase the dose of CBD and decrease the medicine dose.
Speak to Your Veterinarian
Before doing anything, speak with the vet about the probability of an interaction. If there is a probability CBD may interact with your dog or cat’s other meds, be certain to understand how.
Assess the Advantages of CBD for Dogs
Just use CBD when you are certain there isn’t any risk of a negative reaction and that CBD may replace their additional meds. Keep in mind, CBD isn’t any miracle cure and cannot replace every medicine in the market.
Figure out the Proper CBD Dose
Slowly introduce your pet to CBD. Monitor his reaction to the supplement. Begin with smaller doses (0.05mg CBD per pound of body weight) two times per day.
Adjust the Medication and CBD Dosages
As your pet adjusts to CBD, it’s possible to begin to increase their dose (if necessary) and start to decrease the doses of their additional meds. How you do this is going to depend upon what meds he’s taking. Just make certain to do it slowly, because some meds may have nasty side effects as you abruptly stop taking them. Your veterinarian will know how to safely do this.
Basics of CBD Dosages
Generally, CBD oils always are offered in drops.
The precise amount of drops necessary for a dose will vary from product to product, yet usually comprise of 2 to 4 drops taken 2 to 4 times a day.
You also can adjust the dose, given your pet’s size and condition.
On the other hand, CBD capsules typically contain between 5 to 20 milligrams of CBD each.
Once again, the precise quantity of capsules necessary for a dose varies from product to product, yet usually comprises of around one tablet consumed 1 to 2 times a day.
Unlike capsules and oils, CBD treats will contain varying CBD concentrations, and ought to be given to your dog or cat as per the package directions.
Whenever you use any type of CBD, it is recommended to follow the dosing directions which came with the product, seeing how the dog responds then adjusting the dosage as necessary.
Giving Your Dog CBD Oil
CBD oil ideally ought to be directly administered into your dog’s mouth, under the tongue.
As I am certain you know, dogs are not too keen on taking medication; therefore, this might be a bit tricky for some.
But, be patient and keep in mind that your dog might even get accustomed to the regimen of consuming their CBD oil. Most pet owners have claimed that their dogs like to lick it up.
However, if you are experiencing problems administering the liquid, consider rewarding the dog with her/his favorite treat after ingesting the meds.
If that does not work, you might want to think about changing to CBD Treats or CBD capsules, which come to various flavors.
Do not Rush This Process
Be patient. Tapering off of some meds may be a process of weeks or months. Bear in mind, how precisely you taper off your dog’s meds also will vary depending upon how long they have been on their medication, the dosage they have been using, as well as the half-life of their medicine.
Benefits of Weaning Off of Your Dog’s Meds With CBD
To be truthful, I am not one of those people who is against prescription meds.
I value and understand what our medications can do.
However, if you can, I think selecting a natural alternative to traditional medication may offer your dog or cat a ton of health benefits.
CBD is a natural compound that produces pretty much no side effects and is non-toxic.
This means you do not have to be concerned with overdosing:
All of the research into CBD has proven that the only actual side effect it may cause while consumed in large dosages is sedation.
Therefore, if you overdo it with a CBD dose, the worst thing which may occur to your pet is that they’ll feel a little sleepy or drowsy for a while.
That is more than I can say about other popular vet meds that may generate harsh, occasionally even deadly side effects when not properly administered.
CBD also has so many health benefits that it has the ability to increase your dog’s health in several ways.
For users new to CBD oil for dogs, check out our buyer's guide when it comes to buying CBD products for dogs.
For more information about CBD oil for pets please feel free to visit Innovet Pet Products right away!
Sources:CBD and Anxiety
Cannabidiol Eases Pain
Evidence of CBD
CBD and Appetite
Cannabidiol CBD Treatment