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Zyrtec for Dogs - Should You Give Your Dog Zyrtec?

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Zyrtec for Dogs - Should You Give Your Dog Zyrtec?

When Fall quickly overtakes Summer, you may suddenly find yourself suffering from allergies. No one enjoys the itchy eyes and runny noses that come with the changing of the seasons.

While you and your family may be powering through allergies and taking medications to alleviate the symptoms, there's a family member whose allergy struggles might go overlooked..... your dog.

While it may have never crossed most people's minds, your dog can get allergies just the same as you do.

So how do you help your furry friend get through the season?

Recently, a lot of vets have been prescribing Zyrtec for dogs as a method of treating allergies, despite the fact that it isn't FDA approved for animals. Here is what you need to know about giving your dogs Zyrtec.

What is Zyrtec?

Zyrtec is a medication that can be used to treat symptoms of allergic rhinitis. This drug works by blocking histamines, thereby stopping the production of mucus and other congestion in your nose as well as relieving allergy-induced inflammation from inside your nasal passages. Zyrtec also has antihistaminic properties which work on H1 histamine receptors in order to relieve nausea, vomiting, nervousness or sleep disturbances caused from an allergic reaction.

The patented ingredients were developed for people who suffer with severe seasonal allergies but now they are useful for some patients suffering chronic urticaria (hives) because it blocks both itchiness and swelling at localized sites where hives develop best. The Zyrtec dosage for dogs is different than the amount given to treat seasonal allergies in humans. Giving Zyrtec to your dog is against the approved use for the medication and should only be done under the supervision or guidance of your doctor of veterinary medicine. They may provide you with dosing guidelines after insect bites, allergic dermatitis, atopic dermatitis, food allergies, flea allergies, or other allergic reactions.

Why Vets Are Prescribing Zyrtec For Dogs

In case you aren't familiar with using Zyrtec for dogs, it's an allergy medication that can be purchased at your local drug store. It's used to treat symptoms for people and dogs alike; watery or itchy eyes, runny noses, sneezing, hives, and itching. Its comparable to Benadryl, another well-known allergy medication but unlike Benadryl, drowsiness with Zyrtec is often very rare.

Zyrtec's active ingredient, Cetirizine, is an antihistamine commonly used to treat itchy skin in dogs. It's a popular prescription for canines because most dogs tolerate the medication very well and it doesn't have the effect of leaving your pet sedated and lethargic.

With the other allergy-fighting ingredients in Zyrtec and the fact that it can be purchased over the counter, vets often prescribe it as an affordable and effective method for combating your pet's allergies.

While Zyrtec is generally safe for dogs, there are some precautions that you should keep in mind before administering it to your animal.

zyrtec for dogs with allergy symptoms

Precautions Before Giving Your Pet Zyrtec

Never give your dog Zyrtec-D. The "D" stands for pseudoephedrine, which is used to deal with congestion in humans. However, it can have lethal consequences if given to a dog. It overstimulates their central nervous system and heart, causing canine seizures, heart failure, and potentially death.

If your dog struggles with kidney or liver problems, giving them Zyrtec could make the problem worse. This is because Zyrtec can cause urine retention in animals. This isn't too serious of an issue if your dog is healthy beforehand, but it could exacerbate preexisting issues in your pet.

Also, if your dog is nursing, giving h Zyrtec could be very dangerous for the nursing puppies. The ingredients in the allergy prescription can be transferred to the puppies through your dog's milk.

Their bodies are too weak for a strong medication like Zyrtec, and it could lead to serious issues. The same goes for pregnant dogs.

It's also possible that your dog may be allergic to antihistamines. If you give your dog Zyrtec and see a worsening of symptoms or lack of improvement, then they could be having an allergic reaction to the medication.

If this is the case, you should stop administering Zyrtec or any other medications containing antihistamines.

Make sure that you make your vet aware of any other medications that your dog is on before giving them Zyrtec. This is important when giving your pet any kind of medication, as some drug combinations can lead to negative effects.

Zyrtec for dogs precautions and adverse reactions

Correct Dosage Of Zyrtec For Dogs

The safest way to determine the correct amount of Zyrtec to give to your dog is to consult with your vet. Generally, one tablet a day is safe for dogs to take, but the amount can vary greatly depending on your dog's size and symptoms.

What kind of symptoms you are trying to combat in your will determine how much you should be giving them.

The tablets will almost always be administered by mouth to your pet. If given the proper amount, the side effects of the medication should be pretty minimal.

However, giving your dog too high of a dosage can lead to a worsening of symptoms and harmful side effects.

CBD Oil for Dog allergies

Signs Your Dog Is Suffering From an Allergic Reaction

Allergy symptoms can be a little different in dogs than in humans. While we typically will experience itchy or red eyes and a runny nose, your dog's allergies will most likely manifest in different ways.

Common Allergy symptoms include:

If left untreated, these can lead to more severe problems in your dog's overall health, like hair loss and skin infections. A severe allergic reaction could even cause your dog to break out with hives or go into anaphylactic shock, which could be life-threatening.

Your dog could also develop something known as "atopy," which is a hypersensitivity to certain allergens. While not as serious as anaphylactic shock, it can still create serious health problems for your pet. Fortunately, Zyrtec is very effective at combating signs of atopy.

Side Effects Of Zyrtec In Dogs

As long as dogs are given a proper dosage of Zyrtec, side effects are usually nonexistent with this allergy medicine. Generic Zyrtec is one of the safer medications you can give to your dog, so as long as you do so correctly and under your vet's guidance, your pet should be good to go.

Zyrtec is also a difficult medication for a dog to overdose on. They have an extremely high tolerance for it, so long as they aren't allergic to it. It is important to give the correct Zyrtec dosage based on their body weight. It is easy to put too much liquid Zyrtec into pet food.

There have even been tests performed on dogs where they were given more than 200x the normal prescribed amount for a human with no lasting health impacts.

That said, side effects can still occur, and it is always best to be on your guard. If you notice any of these side effects of Zyrtec, stop administering the medication until you consult with your vet on how to address the issue.

The most common side effect of Zyrtec for dogs is drowsiness. It's still relatively rare, but it can occur when your dog is just starting to take the medication, or if the dosage is too high.

Smaller dog breeds are more susceptible to this side effect. Usually, this becomes less severe as your dog adjusts to the medication.

Other side effects include urine retention, vomiting, constipation, high excitement levels, or excessive salivation. Any time you are giving your dog a new medication, keep a close eye on them.

They aren't able to communicate these problems to you as easily as a person could, and rely on you to monitor their wellness.

Alternatives To Giving Your Dog Zyrtec

In the event that your dog does have an adverse reaction to taking Zyrtec, or you prefer a more natural form of allergy treatment, there are viable alternatives to the medication.

One of the natural alternatives to giving your dog Zyrtec is CBD. Studies over the past several decades have shown that cannabidiol can have a significant and positive impact on your pet's well-being. You can find CBD products in the form of dog treatsoils, and even chews. There's no need to hide it in your dog's food or worry about negative side effects. 

Cannabidiol is useful for managing symptoms of dry and itchy skin, cracked paw pads, dull coats, and allergies. It also promotes the health of your dog's skin, helping to reduce shedding and dandruff.

Another natural remedy that is helpful for alleviating allergy symptoms are natural supplements. These are great as well because they are well suited to animals of all ages.


While the idea of giving your dog Zyrtec for their allergy symptoms might seem strange, it's a proven and effective method for helping your pet cope with their dog allergies like itchy skin and maybe even a runny nose. The side effects are minimal, and the positive effects go to work quickly. Dog owners should feel confident that this over the counter antihistamine is a safe way to relieve your furry friend from uncomfortable dog allergies.

Be sure that you consult with your vet beforehand to discuss whether or not Zyrtec could help your pet, and always dose based on their recommendations. And never give your dog Zyrtec-D.

Keep a close eye on your dog's allergy symptoms before and after giving them the medication. If their symptoms worsen or show little signs of improving, then it might be time to consider a safer alternative.


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Approved by:

Dr. Ivana Vukasinovic

Doctor of Veterinary Medicine, University of Belgrade

Ivana Vukasinovic grew up in Serbia and attended the University of Belgrade where she received a degree in Veterinary medicine in 2012 and later completed surgical residency working mostly with livestock. Her first year of practice was split between busy small animal practice and emergency clinic, and after two more years of treating many different species of animals, she opened her own veterinary pharmacy where an interest in canine and feline nutrition emerged with an accent on fighting animal obesity. In her free time, she acts as a foster parent for stray animals before their adoption, likes to read SF books and making salted caramel cookies.


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The Innovet Team

Please do not ask for emergency or specific medical questions about your pets in the comments. Innovet Pet Products is unable to provide you with specific medical advice or counseling. A detailed physical exam, patient history, and an established veterinarian are required to provide specific medical advice. If you are worried that your pet requires emergency attention or if you have specific medical questions related to your pet’s current or chronic health conditions, please contact or visit your local/preferred veterinarian, an animal-specific poison control hotline, or your local emergency veterinary care center.

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